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The Contribution of Morphological Features in the Classification of Prostate Carcinoma in Digital Pathology Images


Nicholas McCarthy, Padraig Cunningham, Gillian O'Hurley

Publication Type: 
Refereed Conference Meeting Proceeding
In this paper we present work on the develop- ment of a system for automated classification of digitized H&E histopathology images of prostate carcinoma (PCa). In our system, images are transformed into a tiled grid from which various texture and morphological features are extracted. We evaluate the contribution of high-level morphological features such as those derived from tissue segmentation algorithms as they relate to the accuracy of our classifier models. We also present work on an algorithm for tissue segmentation in image tiles, and introduce a novel feature vector representation of tissue classes in same. Finally, we present the classification accuracy, sensitivity and specificity results of our system when performing three tasks: distinguishing between cancer and non-cancer tiles, between low and high-grade cancer and between Gleason grades 3, 4 and 5. Our results show that the novel tissue representation outperforms the morphological features derived from tissue segmentation by a significant margin, but that neither feature sets improve on the accuracy gained by features from low-level texture methods.
Conference Name: 
22nd International Conference on Pattern Recognition
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Publication Date: 
Conference Location: 
National University of Ireland, Dublin (UCD)
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